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NOTICE: Kyowa Kirin International has agreed a joint venture with Grünenthal GmbH for the Established Medicines portfolio. The new company, KKI NewCo (known as Grünenthal Meds), is responsible for the content on this page. For more information please click here.​

Gastrointestinal

Opioid-induced Constipation (OIC)

OIC is a common, yet frequently under-recognised, poorly managed complication of opioid therapy.1

  • MEDICAL EDUCATION

    Here you will find educational resources focused on the diagnosis and treatment of OIC. 

  • DISEASE PAGES

    Here you will find expert medical resources delving into the pathology and epidemiology of OIC.

  • MEDICAL RESOURCES

    Here you will find a collection of published data, clinical expertise and guidance for the various treatment options available for OIC.

Chronic Anal Fissure (CAF)

An anal fissure is a tear or open sore (ulcer) that develops in the lining of the large intestine, near the anus. It is a common and painful condition which affects around 1 in 10 people.2

  • MEDICAL EDUCATION

    Access guidelines for the diagnosis and management of chronic anal fissure.

  • DISEASE PAGES

    An introduction to chronic anal fissure, including information on signs and symptoms.

  • MEDICAL RESOURCES

    Explore management options for chronic anal fissure.

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  • References

    1. Farmer A, Drewes A, Chiarioni G, et al. Pathophysiology and management of opioid-induced constipation: European expert consensus statement. United European Gastroenterology Journal. 2019;7(1):7–20.

    2. NHS Anal fissure. Available at: https://www.nhs.uk/conditions/anal-fissure/ Last accessed: July 2022.

    KKI/INT/KKI/0597 November 2023