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NOTICE: Kyowa Kirin International has agreed a joint venture with Grünenthal GmbH for the Established Medicines portfolio. The new company, KKI NewCo (known as Grünenthal Meds), is responsible for the content on this page. For more information please click here.​

Therapy Areas

Gastrointestinal

Opioid-induced Constipation (OIC)

OIC is a common, yet frequently under-recognised, undertreated complication of opioid therapy.1

  • MEDICAL EDUCATION

    Here you will find educational resources focused on the diagnosis and treatment of OIC. 

  • DISEASE PAGES

    Here you will find expert medical resources delving into the pathology and epidemiology of OIC as well as its impact on patient quality of life.

  • MEDICAL RESOURCES

    Here you will find a collection of published data, clinical expertise and guidance for the various treatment options available for OIC.

Gastrointestinal

Chronic Anal Fissure (CAF)

An anal fissure is a tear or open sore (ulcer) that develops in the lining of the large intestine, near the anus. It is a common and painful condition which affects around 1 in 10 people at some point in their life.2

  • MEDICAL EDUCATION

    Access key resources and guidelines for the diagnosis and management of chronic anal fissure.

  • DISEASE PAGES

    An introduction to anorectal disorders and chronic anal fissure, including information on signs and symptoms.

  • MEDICAL RESOURCES

    Explore treatment options and guidance for patients presenting symptoms of chronic anal fissure.

Oncology

Breakthrough Cancer Pain (BTcP)

Transient exacerbations of cancer-related pain, known as BTcP, are a common problem in cancer patients, occurring despite relatively stable, adequately controlled background pain.3

  • MEDICAL EDUCATION

    Here you will find educational resources focused on the diagnosis and treatment of BTcP.

  • DISEASE PAGES

    Here you will find information focused on the characteristics of BTcP and guidance to assist with diagnosis.

  • MEDICAL RESOURCES

    Here you will find information about the impact of BTcP on patients, and treatment options.

Oncology

Chemotherapy-induced Nausea and Vomiting

Chemotherapy-induced nausea and vomiting (CINV) is one of the most distressing and acute side effects of cancer treatment. It can have a significant impact on a patient’s quality of life.4

  • MEDICAL EDUCATION

    Here you will find some frequently asked questions on CINV.

  • DISEASE PAGES

    Here you will find information on chemotherapy-induced nausea and vomiting, including types of CINV, its mechanism and its management.

  • MEDICAL RESOURCES

    Here you will find information about treatment options for CINV.

Bone Health

Calcium & Vitamin D Deficiency

Vitamin D is essential for musculoskeletal health as it promotes calcium absorption from the bowel, enables mineralisation of newly formed osteoid tissue in bone and plays an important role in muscle function.5

  • MEDICAL EDUCATION

    Here you will find links to treatment guidelines for Vitamin D deficiency and osteoporosis.

  • DISEASE PAGES

    Here you will find expert medical resources delving into Vitamin D deficiency and osteoporosis.

  • Medical Resources

    Here you will find a collection of published data, clinical expertise and guidance for the various treatment options available for Vitamin D deficiency and osteoporosis.

Vitamin Deficiency

Alcohol-Related Brain Damage (ARBD)

Alcohol Related Brain Damage describes the effects of changes to the structure and function of the brain resulting from alcohol toxicity and vitamin deficiencies (principally thiamine).6

  • ALCOHOL SCREENING

    Here you will find resources on alcohol screening tools and guidance on conducting a brief intervention.

  • TREATING ALCOHOL DEPENDENCY

    Here you will find information on recommended psychological and medical treatments for patients who drink to a harmful level.

  • CONDITION AND CHANGES

    Access information on alcohol related conditions such as alcohol withdrawal, dual addiction, thiamine deficiency and alcohol related liver disease.

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  • References

    1. Farmer A, Drewes A, Chiarioni G, et al. Pathophysiology and management of opioid-induced constipation: European expert consensus statement. United European Gastroenterology Journal. 2019;7(1):7–20.

    2. NHS Anal fissure. Available at: https://www.nhs.uk/conditions/anal-fissure/ Last accessed: June 2023.

    3. Davies AN et al. BMJ Support Palliative Care 2018;0:1-9. Doi:10.1136/bmjspcare-2017-001467.

    4. National Cancer Institute. Nausea and Vomiting Related to Cancer Treatment. Available at: https://www.cancer.gov/about-cancer/treatment/side-effects/nausea/nausea-hp-pdq/ Last accessed: July 2023.

    5. Royal Osteoporosis Society: Vitamin D and Bone Health: A Practical Clinical Guideline for Patient Management. Available at: https://strwebprdmedia.blob.core.windows. net/media/ef2ideu2/ros-vitamin-d-and-bone-health-in-adults-february-2020.pdf/ Last accessed: November 2023.

    6. Royal College of Psychiatrists College Report CR212. April 2018. https://www.rcpsych.ac.uk/docs/default-source/improving-care/better-mh-policy/college-reports/college-report-cr2121829213d17e3461785bcb073c1529334.pdf?sfvrsn=3924e027_2&msclkid=caa63de9cfdc11ec83519f0ade9ae537 Last accessed: July 2023.

    KKI/UK/GEN/0117 November 2023