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Vitamins B&C Kyowa Kirin Intravenous High Potency, Concentrate for Solution for Infusion

HOW TO PRESCRIBE

Vitamins B&C Kyowa Kirin Intravenous High Potency, Concentrate for Solution for Infusion (Vitamins B&C Kyowa Kirin IVHP) is a parenteral therapy for rapid treatment of severe depletion or malabsorption of the water soluble vitamins B and C, including those related to alcohol misuse and malnutrition.¹

Adverse Events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard. Adverse Events should also be reported to Kyowa Kirin International UK NewCo Ltd, known as Grünenthal Meds on +44 (0)1896 664000, email PVUK@grunenthalmeds.com

Click here for prescribing information.

Prescribing Vitamins B&C Kyowa Kirin IVHP

Some patients may require 3 pairs of ampoules three times daily

*Unless Wernicke’s encephalopathy is excluded

A prescription for Vitamins B&C Kyowa Kirin IVHP for two pairs, three times a day for five days would be:

Vitamins B&C Kyowa Kirin IVHP high potency solution for intravenous infusion:

Is presented in a 6 pair carton containing 12 ampoules.
Each pair consists of two 5ml ampoules (ampoule 1 + ampoule 2) - 10ml in total.

Divided into an easily identifiable paired vial presentation, the Vitamins B&C Kyowa Kirin IVHP treatment pack has been designed to help reduce the risk of dosing and administration errors.

Each pack contains the minimum licensed daily dose of two pairs of ampoules, three times daily.

Contents of Vitamins B & C Kyowa Kirin Intravenous high potency pack

Administration

The licensed adult dose in severe depletion of thiamine that can lead to Wernicke’s encephalopathy is:

2 to 3 pairs of 5ml ampoules, diluted with 50ml to 100ml infusion solution (physiological saline or glucose 5%), administered over 30 minutes every 8 hours.

Always give Vitamins B&C Kyowa Kirin IVHP before or with the administration of carbohydrates or glucose fluids to avoid precipitation of WE.⁴

Ingredients

Vitamins B&C Kyowa Kirin IVHP ingredients

Ampoule 1 (5ml): White stripe around ampoule containing Thiamine hydrochloride BP (250mg), Riboflavin (4mg) (as phosphate sodium VP), Pyridoxine hydrochrloide BP (50mg). Ampoule 2 (5ml): Black stripe around ampoule containing Ascorbic acid BP (500mg), Nicotinamide BP (160mg), Glucose (1ooomg) (as monohydrate)

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References

1. Vitamins B&C Kyowa Kirin Intravenous High Potency, Concentrate for Solution for Infusion Summary of Product Characteristics.

2. Vitamin B substances with ascorbic acid. British National Formulary. https://bnf.nice.org.uk/drugs/vitamin-b-substances-with-ascorbic-acid/ Last accessed June 2024.

3. National Institute for Health and Care Excellence. Full Guidance June 2010. (Updated April 2017). Alcohol use disorders and clinical management of alcohol-related physical complications [Clinical Guidance 100].

4. Hack JB, Hoffman RS. JAMA. 1998; 25;279(8):583-584.

KKI/GB/PAB/0264 June 2024