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Close up of an older person's eye which shows the reflection of a woman drinking, accompanied by 'Look a little deeper. Please look a little deeper and maybe you will find the impact of alcohol misuse that's affecting my mind'

Vitamins B&C Kyowa Kirin Intravenous High Potency, Concentrate for Solution for Infusion

Find out about Vitamins B&C Kyowa Kirin Intravenous High Potency, Concentrate for Solution for Infusion (Vitamins B&C Kyowa Kirin IVHP), a rapid parenteral therapy for treating thiamine deficiency, including those related to alcohol misuse and malnutrition.1

Vitamins B&C Kyowa Kirin IVHP is indicated in adults and children for rapid therapy of severe depletion or malabsorption of the water soluble vitamins B and C:1

  • Particularly in alcoholism, where a severe depletion of thiamine can lead to Wernicke’s encephalopathy
  • After acute infections
  • Post-operatively
  • In psychiatric states

Adverse Events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard. Adverse Events should also be reported to Kyowa Kirin International UK NewCo Ltd, known as Grünenthal Meds on +44 (0)1896 664000, email PVUK@grunenthalmeds.com

Click here for prescribing information.

Alcohol related brain damage (ARBD) is an umbrella term which covers a range of conditions associated with long-term alcohol misuse.2 It can have a devastating effect for sufferers and their families3 and is often under and misdiagnosed.2,4

Wernicke’s encephalopathy (WE) is an acute and life threatening ARBD condition due to severe thiamine deficiency5 and treatment needs to be prompt to ensure early changes to the brain are reversed.6,7

To treat WE, NICE recommends parenteral thiamine (Vitamins B&C Kyowa Kirin IVHP) for a minimum of 5 days.8

Vitamins B&C Kyowa Kirin IVHP

  • INTRODUCTION

    Find out more about treating patients with Vitamins B&C Kyowa Kirin IVHP: a parenteral therapy for treating thiamine deficiency that can help reverse the early changes in the brain caused by thiamine deficiency.1,6,7

  • MODE OF ACTION

    Find out more about why Vitamins B&C Kyowa Kirin IVHP is critical in the treatment of thiamine deficiency for the prevention of alcohol related brain damage seen in Wernicke's encephalopathy.6

  • RESOURCES

    Access resources, recommendations and guidance information, along with useful information on alcohol use and Wernicke's encephalopathy.

  • HOW TO PRESCRIBE

    Guidance on how to prescribe Vitamins B&C Kyowa Kirin IVHP, including dosing, frequency and duration.

  • TOLERABILITY

    Guidance on the most commonly reported side effects and adverse drug reactions.1

  • PRESCRIBING INFORMATION

    Direction on prescribing Vitamins B&C Kyowa Kirin IVHP, covering information from dosing to precautions and contraindications.

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  • References

    1. Vitamins B&C Kyowa Kirin Intravenous High Potency, Concentrate for Solution for Infusion Summary of Product Characteristics.

    2. Alcohol and brain damage in adults. With reference to high-risk groups. College report CR185. May 2014.

    3. Alcohol related brain damage https://stepstocope.co.uk/wp-content/uploads/2019/09/Alcohol-Related-Brain-Damage-ABRD-FS1-1.pdf Last accessed June 2024.

    4. Clinical Review - Alcohol-related brain damage https://www.gponline.com/clinical-review-alcohol-related-brain-damage/neurology/neurology/article/1140755 Last accessed June 2024.

    5. Vasan S, Kumar A. Wernicke Encephalopathy. [Updated 2020 Nov 21]. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan.

    6. Thomson AD, et al. Alcohol Alcohol. 2002; 37(6): 513-521.

    7. Thomson AD. Alcohol Alcohol. 2000; 35(1): 2-7.

    8. Alcohol Use Disorders and Clinical Management of Alcohol Related Physical Complications [Clinical Guidance 100]. National Institute for Health and Care Excellence. Full Guidance June 2010 (updated April 2017).

    KKI/GB/PAB/0260 June 2024